Estimates suggest that 88% of U.S. population growth over the next 50 years will be from immigrants and their offspring. Unfortunately, few evidence based programs have been adapted for use with immigrant populations, and most of those that have been adapted lack rigorous testing to demonstrate their efficacy.  One reason for the lag in developing effective interventions for this rapidly expanding population is the inherent complexity that accompanies working with immigrant populations and how this complexity impacts the transfer of knowledge from efficacy to effectiveness trials and later dissemination. This workshop illustrates the development of the “¡Juntos Se Puede!” (Together We Can!), a USDA/NIFA and National Institutes of Health funded intervention to illustrate the process of T3 translational research with a Latino immigrant population. The workshop will focus on two primary objectives: First, emphasis is placed on the development of community-university collaborations to identify perceived community needs and to foster culturally appropriate interventions through an iterative process of application and evaluation. Second, examples from a feasibility trial collecting biomarker data within a CBPR approach are provided to illustrate the advantages of a biopsychosocial framework for theory development and to increase possible funding opportunities for basic research and intervention trials. Finally, initial results from a study of the feasibility and acceptance of “¡Juntos Se Puede!” implemented with Latino parents and youth, offers evidence of the usefulness of CBPR to address the complexity of translational research with immigrant populations.